Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%
Top Medical Research Studies
8
Magnesium's impact on heart health
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
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9
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
9
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
Most Useful Reviews
9
Supports cardiovascular health
1 people found this helpful
This supplement is excellent for supporting the nervous, muscular, and cardiovascular systems during stress. It contains magnesium in a highly absorbable form, providing effective body support. The pills are conveniently sized, and the stylish packaging is appealing. Besides enhancing sleep and positively impacting the cardiovascular system, it alleviates mild PMS symptoms without swelling or pain. I highly recommend this quality product!
Read More
9
Enhances cardiovascular activity
Perfect product! I recommend it heartily! I've been using it for years. It was recommended by my therapist to boost cardiovascular activity and strengthen the nervous and muscular systems. It aids in calcium absorption and supports healthy bone growth and mineralisation.
Read More
7.5
Overall health improvement
Regular consumption of magnesium enhances the health of both the nervous and cardiovascular systems, as well as overall bodily health. The quality and formulation of this product are excellent.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.4
- All Researches
9
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
9
We examined how vitamin B6, or pyridoxine, might help protect against cardiovascular issues, specifically focusing on its effects in a model of angina in rats. The study involved administering vasopressin, which induced heart stress and ischemia, helping us assess the protective capabilities of pyridoxine.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
During testing, we found that vitamin B6 effectively reduced ST-segment elevation on ECG and lowered heart rate related to the vasopressin-induced angina. Notably, it showed a dose-dependent response, with specific doses of 5 mg and 7 mg per kilogram proving particularly effective.
Interestingly, when we compared pyridoxine to amlodipine, another cardiovascular drug, we observed that pyridoxine not only performed better at reducing cardiac enzymes linked to heart damage but also suggests a novel approach to preventing coronary heart disease. However, combining pyridoxine with amlodipine raised concerns about increased adverse cardiovascular events, indicating that while pyridoxine may enhance heart protection, pairing it with certain medications could complicate treatment.
Given these findings, we believe that vitamin B6 at optimal doses may hold promise for heart disease prevention and deserves further exploration in clinical settings.
Read More
9
We investigated the potential of vitamin B6, in the form of pyridoxal-5'-phosphate (PLP), to influence blood pressure, particularly in the context of hypertension. Our focus was on how PLP modifies angiotensin II, a peptide that plays a critical role in blood vessel constriction, transforming it into a different form known as pyruvamide-Ang II (Ang P).
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
By examining this transformation, we looked into its effects on calcium entry in vascular smooth muscle cells (VSMCs) as well as its binding affinity to blood pressure receptors. Through laboratory experiments using both spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), we found that those treated with PLP experienced a significant drop in blood pressure, while the control group showed an increase after receiving angiotensin II.
This suggests that PLP could be an effective, low-cost option for managing hypertension, potentially offering a new path for treatment. Increasing PLP intake could help hypertensive individuals manage their condition more effectively and affordably.
Read More
9
We set out to understand whether vitamin B-6 has preventive effects on heart failure with preserved ejection fraction (HFpEF), a condition often associated with changes in heart macrophages. To test this, we used a mouse model where we induced HFpEF through a combination of a high-fat diet and a specific supplement.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
By assessing the cardiac function using echocardiography, we were able to track how the inclusion of vitamin B-6 impacted various heart issues related to HFpEF. Our findings were quite promising: when vitamin B-6 was administered alongside the HFpEF diet, we saw significant improvements in several key areas.
The E/E' ratio—a measure of heart function—dropped considerably, from 42.0 down to 21.6, while the E/A ratio improved, indicating better heart operation. Moreover, the mice displayed enhanced exercise capacity. However, it was interesting to note that these positive outcomes vanished in mice lacking the DOK3 protein, suggesting that vitamin B-6 plays a role in regulating signaling pathways that affect the function of heart macrophages.
Overall, our study indicates that vitamin B-6 could be a valuable therapeutic approach to mitigate the effects of HFpEF by preventing harmful changes in macrophage function, thereby supporting heart health.
Read More
9
Vitamin B6 shows uncertain cardiovascular effects
We conducted a study to assess the potential benefits of vitamin B6, along with other B vitamins, in lowering homocysteine levels and reducing bad cholesterol (LDL-C) in individuals at risk for cardiovascular disease due to specific genetic polymorphisms.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Our research included a randomized, double-blind, placebo-controlled trial with 54 participants aged between 40 and 75, all of whom had elevated homocysteine and moderate LDL-C levels. Over a six-month period, those receiving a combination of methylfolate, pyridoxal-5'-phosphate (vitamin B6), and methylcobalamin showed a significant reduction in both homocysteine by 30% and LDL-C by 7.5%, compared to those who received a placebo.
Particularly interesting were the findings regarding the subgroup of participants with homozygous minor allele polymorphisms, who experienced even larger decreases in homocysteine levels and LDL-C compared to mixed allele carriers. While vitamin B6 was part of the effective combination, we must note that its individual effect on cardiovascular disease remains uncertain, as the study primarily evaluates the combined effect of the B vitamins.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports cardiovascular health
1 people found this helpful
This supplement is excellent for supporting the nervous, muscular, and cardiovascular systems during stress. It contains magnesium in a highly absorbable form, providing effective body support. The pills are conveniently sized, and the stylish packaging is appealing. Besides enhancing sleep and positively impacting the cardiovascular system, it alleviates mild PMS symptoms without swelling or pain. I highly recommend this quality product!
Read More
9
Enhances cardiovascular activity
Perfect product! I recommend it heartily! I've been using it for years. It was recommended by my therapist to boost cardiovascular activity and strengthen the nervous and muscular systems. It aids in calcium absorption and supports healthy bone growth and mineralisation.
Read More
7.5
Overall health improvement
Regular consumption of magnesium enhances the health of both the nervous and cardiovascular systems, as well as overall bodily health. The quality and formulation of this product are excellent.
Read More
6
Prevents cardiovascular diseases
This product is ideal for those experiencing sleep issues, chronic stress, or office-related fatigue. It also aids in preventing cardiovascular diseases and supports the nervous system. The packaging is commendable, and it comes from a reputable company.
Read More
Frequently Asked Questions
7.5
Overall health improvement
Regular consumption of magnesium enhances the health of both the nervous and cardiovascular systems, as well as overall bodily health. The quality and formulation of this product are excellent.
9
Enhances cardiovascular activity
Perfect product! I recommend it heartily! I've been using it for years. It was recommended by my therapist to boost cardiovascular activity and strengthen the nervous and muscular systems. It aids in calcium absorption and supports healthy bone growth and mineralisation.
9
Supports cardiovascular health
1 people found this helpful
This supplement is excellent for supporting the nervous, muscular, and cardiovascular systems during stress. It contains magnesium in a highly absorbable form, providing effective body support. The pills are conveniently sized, and the stylish packaging is appealing. Besides enhancing sleep and positively impacting the cardiovascular system, it alleviates mild PMS symptoms without swelling or pain. I highly recommend this quality product!
6
Prevents cardiovascular diseases
This product is ideal for those experiencing sleep issues, chronic stress, or office-related fatigue. It also aids in preventing cardiovascular diseases and supports the nervous system. The packaging is commendable, and it comes from a reputable company.
9
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
8
Magnesium linked to cardiovascular health
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
8
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
8
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
References
- Yu H, Zhou C, Yang S, Yu J, Zhang X, et al. Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium. Biomaterials. 2025;319:123135. doi:10.1016/j.biomaterials.2025.123135
- Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. doi:10.1093/ckj/sfae390
- Wang F, Mao Y, Sun J, Yang J, Xiao L, et al. Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes. Sci Rep. 2025;15:4600. doi:10.1038/s41598-025-88480-9
- Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. doi:10.6133/apjcn.202502_34(1).0010
- Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. doi:10.1038/s41598-025-85931-1
- Nielsen FH. The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients. 2024;16. doi:10.3390/nu16234223
- Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. doi:10.1684/mrh.2024.0528
- Urbanowicz T, Hanć A, Frąckowiak J, Piecek J, Spasenenko I, et al. The Hypothesis of Trace Elements Involvement in the Coronary Arteries Atherosclerotic Plaques' Location. J Clin Med. 2024;13. doi:10.3390/jcm13226933
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- Shahsavani Z, Masoumi SJ, Barati-Boldaji R, Shamshirgardi E, Kafipour R, et al. Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases. Biol Trace Elem Res. 2025. doi:10.1007/s12011-025-04587-0
- Pariona-Vargas F, Mun KT, Lo EH, Starkman S, Sanossian N, et al. Is there diurnal variation in neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?. J Stroke Cerebrovasc Dis. 2025;34:108278. doi:10.1016/j.jstrokecerebrovasdis.2025.108278
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. doi:10.1186/s12906-025-04809-x
- Zhang RY, Chen Y, Yan XQ, Zhang Y, Zhou H, et al. Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study. Front Nutr. 2025;12:1545301. doi:10.3389/fnut.2025.1545301
- Al-Khawlani MA, Al-Madhagi WM, Sabati AM, ALomaisi SAMA, Al-Najar M. Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats. Naunyn Schmiedebergs Arch Pharmacol. 2025. doi:10.1007/s00210-025-03905-6
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413
- Lellig M, Rodríguez M, López-Baltanás R, Hermann J, Wollenhaupt J, et al. Pyridoxal-5'-phosphate: A cost-effective treatment candidate for hypertensive patients?. J Intern Med. 2024;296:435. doi:10.1111/joim.20015
- Rafinezhad M, Kheirouri S, Abbasnezhad M, Alizadeh M. What Dietary Vitamins and Minerals Might Be Associated with Paraoxonase-1 Serum Levels in Patients with Coronary Artery Disease?. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04382-3
- Ren W, Li Y, Lu C, Liu S, Shao Y, et al. Comprehensive assessment on the association of dietary vitamins with all-cause and cardiovascular mortality among individuals with prediabetes: evidence from NHANES 1999-2018. Food Funct. 2024;15:10037. doi:10.1039/d4fo02893g
- Dong G, Xu W, Xu L. Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16172818
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. doi:10.1038/s41598-024-68413-8
- Song JW, Zhang ZS, Chen L, Wang QW, Xu JY, et al. Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model. J Nutr. 2024;154:3031. doi:10.1016/j.tjnut.2024.08.006
- Pokushalov E, Ponomarenko A, Bayramova S, Garcia C, Pak I, et al. Effect of Methylfolate, Pyridoxal-5'-Phosphate, and Methylcobalamin (Soloways) Supplementation on Homocysteine and Low-Density Lipoprotein Cholesterol Levels in Patients with Methylenetetrahydrofolate Reductase, Methionine Synthase, and Methionine Synthase Reductase Polymorphisms: A Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16111550
- Wang P, Huang J, Xue F, Abuduaini M, Tao Y, et al. Associations of serum vitamin B6 status with the risks of cardiovascular, cancer, and all-cause mortality in the elderly. Front Immunol. 2024;15:1354958. doi:10.3389/fimmu.2024.1354958
- Haesen S, Verghote E, Heeren E, Wolfs E, Deluyker D, et al. Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells. Cells. 2024;13. doi:10.3390/cells13020120
- Haesen S, Jager MM, Brillouet A, de Laat I, Vastmans L, et al. Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13010112
